We live in a time of continuous change. Regions with the ability to understand, anticipate and prepare for alternative future scenarios are rewarded in the New Economy. Strategic actions will improve the prospect for the Twin Cities to be globally competitive in the New Economy. The purpose of this paper is to ask the right questions and engage the right people in a common understanding of how to improve the likelihood for impact and sustained change. As initial steps in a process of strategy-making our region's leaders need to review assessments of the region, consider opportunities, choose priorities, and define roles and responsibilities for action.