Explore Issue Areas

  • Aging
  • Agriculture and Food
  • Animal Welfare
  • Arts and Culture
  • Athletics and Sports
  • Children and Youth
  • Civil Society
  • Community and Economic Development
  • Computers and Technology
  • Consumer Protection
  • Crime and Safety
  • Disabilities
  • Education and Literacy
  • Employment and Labor
  • Energy and Environment
  • LGBTQI
  • Government Reform
  • Health
  • Housing and Homelessness
  • Human Rights and Civil Liberties
  • Humanitarian and Disaster Relief
  • Hunger
  • Immigration
  • International Development
  • Journalism and Media
  • Men
  • Nonprofits and Philanthropy
  • Parenting and Families
  • Peace and Conflict
  • Poverty
  • Prison and Judicial Reform
  • Race and Ethnicity
  • Religion
  • Science
  • Substance Abuse and Recovery
  • Transportation
  • Welfare and Public Assistance
  • Women

Explore Collections

Special Collections are curated collections of research that address a specific topic or research question.

  • IssueLab Results is #OpenForGood

  • Democracy Special Collection

  • Gun Violence Special Collection

  • Immigration Strategies Special Collection

  • Affordable Care Act Special Collection

  • Race and Policing Special Collection

View All

Knowledge Centers are a custom service of IssueLab providing organizations with a simple way to manage and share knowledge on their own websites.

  • New York Foundation Knowledge Center

  • European Foundation Centre Knowledge Center

  • TrustAfrica's African Giving Knowledge Center

View All
Get our monthly emails
  • Help
  • Sign in
  • Upload
  • Issue Areas
  • Collections
  • Services
  • About
  • News

Please login first to save in your collection.

LOGIN

SAVE TO MY LIBRARY

My Collection (0)


Visit My Library
GET EMAILS UPLOAD

Environmental biodiversity, human microbiota, and allergy are interrelated

by Erkki Vartiainene; Harri Aleniusc; Ilkka Hanskia; Kaisa Torppaa; Kaisa Koskinend; Lars Paulind; Leena Von Hertzenb; Mika J. Mäkelä; Nanna Fyhrquistc; Petri Auvinend; Piia Karisolac; Tari Haahtelab; Tiina Laatikainene; Timo U. Kosunenf

Apr 4, 2012
  • Health

  • DESCRIPTION

Rapidly declining biodiversity may be a contributing factor to another global megatrend--the rapidly increasing prevalence of allergies and other chronic inflammatory diseases among urban populations worldwide. According to the "biodiversity hypothesis," reduced contact of people with natural environmental features and biodiversity may adversely affect the human commensal microbiota and its immunomodulatory capacity. Analyzing atopic sensitization (i.e., allergic disposition) in a random sample of adolescents living in a heterogeneous region of 100 ? 150 km, we show that environmental biodiversity in the surroundings of the study subjects' homes influenced the composition of the bacterial classes on their skin. Compared with healthy individuals, atopic individuals had lower environmental biodiversity in the surroundings of their homes and significantly lower generic diversity of gammaproteobacteria on their skin. The functional role of the gram-negative gammaproteobacteria is supported by in vitro measurements of expression of IL-10, a key anti-inflammatory cytokine in immunologic tolerance, in peripheral blood mononuclear cells. In healthy, but not in atopic, individuals, IL-10 expression was positively correlated with the abundance of the gammaproteobacterial genus Acinetobacter on the skin. These results raise fundamental questions about the consequences of biodiversity loss for both allergic conditions and public health in general.

More

Environmental biodiversity, human microbiota, and allergy are interrelated

Download Via DOI

Save To Library

Share Via

Suggest an edit

WHAT TO READ NEXT

  • Pandemic Flu and the Potential for U.S. Economic Recession: A State-by-State Analysis
  • Transforming the Workforce to Provide Better Chronic Care: The Role of Nurse Care Managers in Rhode Island
  • New Report Provides Evidence for Expanding the Dental Care Workforce

DOI:

  • doi.org/10.1073/pnas.1205624109

Published By

  • Proceedings of the National Academy of Sciences of the United States of America (PNAS)

Funded By

  • European Research Council
  • Finnish CoE Programme 2006-2011
  • Academy of Finland Grants
  • Helsinki University Hospital
  • Juselius Foundation
  • Liv och H?lsa Foundation

Copyright

  • Copyright 2012 Proceedings of the National Academy of Sciences of the United States of America.

Document Type

  • Report/Whitepaper

Language

  • English
Linked Data show/hide

This web page is marked up with Schema.org microdata and formatted for machine-reading. Here's why that matters. Have a peek at what a machine sees here .

Title: Environmental biodiversity, human microbiota, and allergy are interrelated
Publication date 2012-04-04
Publication Year 2012
Authors Erkki Vartiainene , Harri Aleniusc , Ilkka Hanskia , Kaisa Torppaa , Kaisa Koskinend , Lars Paulind , Leena Von Hertzenb , Mika J. Mäkelä , Nanna Fyhrquistc , Petri Auvinend , Piia Karisolac , Tari Haahtelab , Tiina Laatikainene , Timo U. Kosunenf
Copyright holder(s) Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Document type Report/Whitepaper
Language English
URL: https://www.issuelab.org/resource/environmental-biodiversity-human-microbiota-and-allergy-are-interrelated.html
Resource provided by IssueLab

Get free, worthwhile monthly emails from IssueLab!

IssueLab
  • About
  • News
  • Services
Join Us
  • Add to Issuelab
  • Open Knowledge
  • Use Our Data
Support
  • FAQ
  • Contact Us
  • Privacy Policy
  • ToS

Subscribe to our mailing list

There was an error with registration, please try again
Successfully registered!