Racial/ethnic and sexual minority males are two of the most persistently unhealthy groups in the United States. In fact, health disadvantages are even more pronounced among groups of boys and men who have not fully enjoyed the socioeconomic power and privilege typically conferred to males in this country. These are boys and men at the intersections of social identities, communities, or groups that have historically been oppressed, marginalized, and stigmatized. Moreover, they are boys and men with lived experiences, occupations, or material circumstances that disconnect them from day-to-day society. Often, these males have some of the most negative health-related outcomes, including shorter lifespans, more threats to their safety and well-being, and less access to health care and social supports.