This report offers a first step toward defining the range of potential economic consequences to the Midwest if we continue on our current greenhouse gas emissions pathway. The research combines state-of-the-art climate science projections through the year 2100 (and beyond in some cases) with empirically-derived estimates of the impact of projected changes in temperature and precipitation on the Midwest economy. The authors analyze not only those outcomes most likely to occur, but also lower-probability, higher-cost climate futures. These are the "tail risks," most often expressed here as the 1-in-20 chance something will occur. Unlike any other study to date, this report looks at climate impacts at a very geographically granular level, in some cases providing county-level results.