In the summer of 2004, then-U.S.Senate candidate from Illinois Barack Obama galvanized the nation with a message centered on the hope, promise,and power of the American dream. He said Americans possess the "audacity of hope," which, as much as any phrase of recent origin, describes the impetus behind both the conduct and support of medical research. This is not mere rhetoric. More than the citizens of any other nation, Americans support medical research. Today, there are approximately 35 million Americans ages 65 and older who, because of improvements in health care and nutrition, are more likely than ever to be healthy, vigorous, and productive.