This document examines the contribution of microfinance institutions (MFIs) on the performance of small and medium enterprises (SMEs) and the empowerment of women in Burundi. Its overall objective is to analyze the impact of the services of MFIs on SMEs and women's empowerment. Several specific objectives were formulated and analyses were guided by two assumptions: MFIs are the main source of funding for MFIs one hand, and they are a lever of empowerment of women. The study uses in its methodological aspect a combination of statistical approaches. The study focused on three targets: the IMF on the supply side, SMEs and Beneficiaries of ECCS on the demand side.