This study is based on an extensive literature review and more than 50 interviews with a broad specturm of foundation leaders, academic experts, EU officials, and staff of ESPII organizations. The results are like a health check up of our sector. They show that not everything is perfect in this system, a system that many of us have helped to shape over the last 25 years. We should make sure that the health indicators of the European Philanthropy and Social Investment Infrastructure are in good shape for the next 25 years. We need this infrastructure to represent our sector, to drive innovations and to increase in the impact of our work. The latter is very much connected to tackling some of the most pressing issues of our time.