This report covers four main topics related to Practical Cure progress. First, it assesses the significant impact that type 1 has on many Americans. Of particular note here is donors' strong support for a Practical Cure. Second, our review of Practical Cure research reveals that while medical science has made little material progress toward a type 1 cure in the past year, there are a few encouraging developments which can provide opportunities for future progress. Third is the analysis of managerial practices at the major diabetes non-profits finds a distinct misalignment between donor wishes and the non-profits' actual use of donor contributions. Finally, we recommend action steps that donors can take to drive substantive change in 2014.