"Sustainability" is apparently reflected in corporate management and product development. Technology development and industrial revolution not only provide human beings luxury living quality but also causes global environmental problems and natural resources crisis on earth. Therefore, quite a few environmental protection policies in the world have been made. "Reduce, reuse and recycle" definitely becomes a new life trend. Under this circumstance, Product Service System (PSS) is a new way to satisfy the customers' needs by means of a complete process in products and services. It can make resource usage become a closed loop, thus reducing total product quantity and enhancing resource usage sufficiency. PSS has a characteristic of lower environmental impacts. Therefore, the author incorporates the concept of PSS into sustainable design strategy. This study first utilizes Analytic Network Process (ANP) to analyze both service categories from PSS and ranking priority of life cycle structure to be the foundation of sustainable design. Secondly, this study adopts Modified Delphi（MD）method to inspect the sustainable design factors considered for the application of PSS on case study. Furthermore, the author develops evaluation guidance and check list to make sure the target achievement of product sustainable design. Finally, this research accomplishes an applied process of PSS's sustainable design. By employing PSS on sustainable design, the study improves the impact of product life cycle on environmental quality. As a result, this study provides the PSS's design factors considered of sustainable products for corporations, and supplies a continuous service to create an operation mechanism with higher profit and lower risk as well.